The Division of Science offers the B.A. degree with majors in biology, chemistry, and mathematics; and the B.S. degree with majors in applied computer science, biology, chemistry, forensic computer science, forensic science, medical technology, mathematics, pre-medicine, and pre-dentistry. Additional courses are offered in physics and physical science. Students who make proper arrangements may take specialized courses at Clemson University through the cooperative program. The chair of the division and the health professions advisor are available to assist students wishing to prepare for graduate or professional school, such as medical school, graduate study in a science field, physical therapy, or health information administration, or who wish to transfer to a specialized program such as nursing, veterinary medicine, podiatry, or cytotechnology.

All majors in the division are required to take a comprehensive oral examination during their senior year.

All majors in biology, chemistry, mathematics, pre-medicine, or pre-dentistry are required to take the Major Field Test in the major area (pre-dentistry and pre-medicine majors may choose either the biology or chemistry test) as seniors and have the scores sent to the chair of the division. First-semester students who have identified themselves as such a major, and who are taking a course toward that major, will also be required to take this test.

All Sophomore Applied Computer Science majors, including transfer students, are required to take and pass an entrance exam, based on the 100 and 200 level computer science courses, before they may be admitted to 300 and 400 level computer science courses. A grade of 2.5 or better on a 100 and 200 level computer courses at Southern Wesleyan University or equivalent college transfer courses from any regionally accredited institution will exempt the student from the portion of the exam drawn from that course. Successfully passing the sophomore exam by scoring at least a 2.0 on each portion of the exam allows a student to move on to 300 and 400 level computer science courses. Individual portions of the exam may be retaken one time or the courses represented by those portions of the exam may be retaken.